Feature Summary

Enhanced B Complex from Bioclinic Naturals is a one-per-day formula providing full-spectrum B vitamins in their most metabolically active forms. B vitamins are cofactors for many important mechanisms in the body, including nutrient metabolism, energy production, growth and development, and liver function. B vitamins also help support immunity, red blood cell production, and iron metabolism, as well as healthy skin, hair, and nails. This formula contains B vitamins in their active forms, such as vitamins B12 (methylcobalamin) and B6 (pyridoxal 5’-phosphate), to support nervous system function. It also includes 50 mg of choline and 400 mcg of folate (Quatrefolic). In addition, this formula contains vitamins B1, B2, B5, and B6, and niacin, with additional support from biotin and inositol. This convenient all-in-one B complex is an ideal supplement to help support metabolism, energy, and overall health.

Quatrefolic is an active form of folate at the cellular level, the form found in circulation and the only one to cross the blood-brain barrier. It may also be the optimal form for preventing neural tube defects.(1) It does not need to be converted to an active form by the enzyme methylene tetrahydrofolate reductase (MTHFR), known to have common single-nucleotide polymorphisms.(2) Quatrefolic acid administration has been associated with higher peak (6S)-5-MTHF levels than both folic acid and calcium 5-MTHF, even in those with high-functioning MTHFR polymorphisms.(2–4)

Methylcobalamin is a cofactor for B12-dependent enzymes and has direct biological activity. When combined with other B vitamins, it has been shown to reduce the risk of macular degeneration migraines, with effectiveness sometimes modulated by MTHFR status.(5–8)